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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MDM2 All Species: 12.73
Human Site: S253 Identified Species: 31.11
UniProt: Q00987 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00987 NP_001138811.1 491 55233 S253 S V E F E V E S L D S E D Y S
Chimpanzee Pan troglodytes XP_001155208 497 56032 S259 S V E F E V E S L D S E D Y S
Rhesus Macaque Macaca mulatta XP_001117336 491 55228 S253 S V E F E V E S L D S E D Y S
Dog Lupus familis XP_536098 519 58173 G279 V S E Q F G V G I K V E A A D
Cat Felis silvestris
Mouse Mus musculus P23804 489 54525 D253 E F E V E S L D S E D Y S L S
Rat Rattus norvegicus Q5XIN1 490 55202 G253 V S E Q L G V G V K V E A A N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511571 475 53775 E256 S H N E E G Q E L T D E D D E
Chicken Gallus gallus XP_417957 481 54617 T258 N T A V K M E T A D C E E V K
Frog Xenopus laevis P56273 473 53446 H254 Y S P S G D E H G V S E E E E
Zebra Danio Brachydanio rerio O42354 445 49931 Y239 E S I N S D A Y S E N D V D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 99.3 32.7 N.A. 81.4 32.5 N.A. 69.8 30.9 56.2 45.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.7 99.8 52.9 N.A. 87.7 52.5 N.A. 82.4 51.9 72.5 59.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 13.3 N.A. 20 13.3 N.A. 33.3 20 20 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 26.6 26.6 N.A. 40 53.3 26.6 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 10 0 10 0 0 0 20 20 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 0 0 0 0 0 20 0 10 0 40 20 10 40 20 10 % D
% Glu: 20 0 60 10 50 0 50 10 0 20 0 80 20 10 20 % E
% Phe: 0 10 0 30 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 10 30 0 20 10 0 0 0 0 0 0 % G
% His: 0 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 10 0 0 0 0 20 0 0 0 0 10 % K
% Leu: 0 0 0 0 10 0 10 0 40 0 0 0 0 10 0 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 10 10 0 0 0 0 0 0 10 0 0 0 10 % N
% Pro: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 20 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 40 40 0 10 10 10 0 30 20 0 40 0 10 0 50 % S
% Thr: 0 10 0 0 0 0 0 10 0 10 0 0 0 0 0 % T
% Val: 20 30 0 20 0 30 20 0 10 10 20 0 10 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 10 0 0 0 10 0 30 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _